Discovery of a high affinity inhibitor of cGAS

Code: 6NAO
Classification: transferase/transferase inhibitor
Resolution: 3.23 Å
R-factor: 0.217
Keywords: cGAS, STING, cGAMP, TRANSFERASE, transferase-transferase inhibitor complex
Deposition Date: 6 December, 2018
Experimental Technique: X-RAY DIFFRACTION
Source Organism:
Expression System:
Biological Assembly: 1

Zinc-Bearing Chains in PDB

1 zinc-bearing chain
Chain A (362 residues; 1 zinc binding site; Spacers: 5, 0, 6 )
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Zinc atoms identified in PDB

2 zinc atoms
(B:601, A:601)

Zinc atoms not used

B:601: Zinc in asymmetric unit but not biological assembly.
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