Crystal structure of an alcohol dehydrogenase from Elizabethkingia anophelis NUHP1

Code: 6N7L
Classification: OXIDOREDUCTASE
Resolution: 2.1 Å
R-factor: 0.149
Keywords: NIAID, National Institute of Allergy and Infectious Disease, zinc-dependent enzyme, metalloenzyme, unknown substrate, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, SSGCID, OXIDOREDUCTASE
Deposition Date: 27 November, 2018
Experimental Technique: X-RAY DIFFRACTION
Source Organism:
Expression System:
Biological Assembly: 1

Zinc-Bearing Chains in PDB

4 zinc-bearing chains
Chain A (353 residues; 2 zinc binding sites; Spacers: 22, 29, 2, 2, 7, 41 )
mahhhhhhmipktmkaavvqgygeplkiqevpvrepgryevlvkvmacgvChtdlhavdgdwpakpkmplipgHegvgivvacgpdamvkegdavgvpwlysaCgcCdyCitgwetlCeaqqnggysvdggfaeyviadsryvghlksnvnfleiapilCagvtvykglketetkpgewvaisgigglghvavqyakamgmhvaaidvaddklelakklgadltvnakttdpgtylhkevggmhgalitavspiafkqgidvlrrkgtialnglppgsfelpifetvlkritvrgsivgtrkdlqealdfaneglvkatvtsakledindvfdkmkkgqidgrivldiagsqn
Chain B (353 residues; 2 zinc binding sites; Spacers: 22, 29, 2, 2, 7, 41 )
mahhhhhhmipktmkaavvqgygeplkiqevpvrepgryevlvkvmacgvChtdlhavdgdwpakpkmplipgHegvgivvacgpdamvkegdavgvpwlysaCgcCdyCitgwetlCeaqqnggysvdggfaeyviadsryvghlksnvnfleiapilCagvtvykglketetkpgewvaisgigglghvavqyakamgmhvaaidvaddklelakklgadltvnakttdpgtylhkevggmhgalitavspiafkqgidvlrrkgtialnglppgsfelpifetvlkritvrgsivgtrkdlqealdfaneglvkatvtsakledindvfdkmkkgqidgrivldiagsqn
Chain C (353 residues; 2 zinc binding sites; Spacers: 22, 29, 2, 2, 7, 41 )
mahhhhhhmipktmkaavvqgygeplkiqevpvrepgryevlvkvmacgvChtdlhavdgdwpakpkmplipgHegvgivvacgpdamvkegdavgvpwlysaCgcCdyCitgwetlCeaqqnggysvdggfaeyviadsryvghlksnvnfleiapilCagvtvykglketetkpgewvaisgigglghvavqyakamgmhvaaidvaddklelakklgadltvnakttdpgtylhkevggmhgalitavspiafkqgidvlrrkgtialnglppgsfelpifetvlkritvrgsivgtrkdlqealdfaneglvkatvtsakledindvfdkmkkgqidgrivldiagsqn
Chain D (353 residues; 2 zinc binding sites; Spacers: 22, 29, 2, 2, 7, 41 )
mahhhhhhmipktmkaavvqgygeplkiqevpvrepgryevlvkvmacgvChtdlhavdgdwpakpkmplipgHegvgivvacgpdamvkegdavgvpwlysaCgcCdyCitgwetlCeaqqnggysvdggfaeyviadsryvghlksnvnfleiapilCagvtvykglketetkpgewvaisgigglghvavqyakamgmhvaaidvaddklelakklgadltvnakttdpgtylhkevggmhgalitavspiafkqgidvlrrkgtialnglppgsfelpifetvlkritvrgsivgtrkdlqealdfaneglvkatvtsakledindvfdkmkkgqidgrivldiagsqn

Zinc atoms identified in PDB

24 zinc atoms
(K:406, K:407, L:405, L:406, F:412, I:408, E:411, E:412, F:413, I:409, H:708, J:409, H:709, J:410, G:509, G:510, A:413, A:414, B:409, B:410, C:414, C:415, D:510, D:511)

Zinc atoms not used

K:406: Zinc in asymmetric unit but not biological assembly.
K:407: Zinc in asymmetric unit but not biological assembly.
L:405: Zinc in asymmetric unit but not biological assembly.
L:406: Zinc in asymmetric unit but not biological assembly.
F:412: Zinc in asymmetric unit but not biological assembly.
I:408: Zinc in asymmetric unit but not biological assembly.
E:411: Zinc in asymmetric unit but not biological assembly.
E:412: Zinc in asymmetric unit but not biological assembly.
F:413: Zinc in asymmetric unit but not biological assembly.
I:409: Zinc in asymmetric unit but not biological assembly.
H:708: Zinc in asymmetric unit but not biological assembly.
J:409: Zinc in asymmetric unit but not biological assembly.
H:709: Zinc in asymmetric unit but not biological assembly.
J:410: Zinc in asymmetric unit but not biological assembly.
G:509: Zinc in asymmetric unit but not biological assembly.
G:510: Zinc in asymmetric unit but not biological assembly.
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