Zinc Binding Site: 6NFG-1

PDB

6NFG (CYCLIC GMP-AMP SYNTHASE in complex with compound 16 inhibitor: 7-hydroxy-N-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-3-carboxamide)

Metals (4 Coordination)

A:601 (ZN)

Liganding Residues (C3H1)

A.390 (HIS)
A.396 (CYS)
A.397 (CYS)
A.404 (CYS)
24 equivalent sites.
4KM5-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
4LEV-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
4LEV-2
residues B.390 (HIS), B.396 (CYS), B.397 (CYS), B.404 (CYS)
4LEW-1
residues B.390 (HIS), B.396 (CYS), B.397 (CYS), B.404 (CYS)
4MKP-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
4O67-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
4O67-2
residues B.390 (HIS), B.396 (CYS), B.397 (CYS), B.404 (CYS)
4O68-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
4O69-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
5V8O-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
5V8O-2
residues B.390 (HIS), B.396 (CYS), B.397 (CYS), B.404 (CYS)
5VDO-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
5VDP-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
5VDQ-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
5VDR-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
5VDS-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
5VDT-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
5VDU-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
5VDV-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
5VDW-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
6CT9-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
6CTA-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
6NAO-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
6NFO-1
residues A.390 (HIS), A.396 (CYS), A.397 (CYS), A.404 (CYS)
Download image

Chain A Spacers: 5, 0, 6

gasklravleklklsrddistaagmvkgvvdhlllrlkcdsafrgvgllntgsyyehvkisapnefdvmfklevpriqleeysntrayyfvkfkrnpkenplsqflegeilsaskmlskfrkiikeeindikdtdvimkrkrggspavtllisekisvditlalesksswpastqeglriqnwlsakvrkqlrlkpfylvpkhakegngfqeetwrlsfshiekeilnnHgksktCCenkeekCcrkdclklmkylleqlkerfkdkkhldkfssyhvktaffhvctqnpqdsqwdrkdlglcfdncvtyflqclrteklenyfipefnlfssnlidkrskefltkqieyernnefpvfdef

PDB Information

Code: 6NFG
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Resolution: 2.76 Å
R-factor: 0.182
Keywords: cGAS, STING, cGAMP, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposition Date: 20 December, 2018
Experimental Technique: X-RAY DIFFRACTION
Source Organism:
Expression System:
Biological Assembly: 1